洛美沙星注射液与注射用阿昔洛韦配伍稳定性考察

Study on compatibility of lomefloxacin aspartate injection with aciclovir injection

目的考察门冬氨酸洛美沙星注射液与注射用阿昔洛韦在5%葡萄糖注射液(GS)中配伍的稳定性。方法在25、37℃下,模拟临床常用浓度,将洛美沙星注射液与注射用阿昔洛韦在5%GS中配伍,观察6 h内的配伍液外观、扫描紫外光谱、pH值、洛美沙星及阿昔洛韦含量的变化。结果门冬氨酸洛美沙星注射液在配伍前后pH值有明显变化,注射用阿昔洛韦的pH值变化不明显;25℃时,注射用阿昔洛韦的含量均>90%,37℃时含量均<90%。结论门冬氨酸洛美沙星注射液与注射用阿昔洛韦在5%GS中不宜配伍使用。

Objective To study the stability of lomefloxacin（LFLX） aspartate injection and acyclovir（ACV） for injection in 5 % Glucose injection. Methods The mixed solution was laid for 6 hours at 25 ℃ and 37℃, then the appearance and pH were observed, and the UV spectrophotometry was developed respectively. Results The pH of LFLX was changed significantly before and after mixing, and the content of ACV was 〈 90 % at 37℃ . Conclusion The preparations can not be used together in 5 % glucose injection.