卵巢浆液性和黏液性肿瘤中粘蛋白MUC1的表达

EXPRESSION OF MUCIN MUC1 IN SEROUS AND MUCINOUS OVARIAN TUMORS

目的:探讨卵巢浆液性和黏液性肿瘤中黏蛋白MUC1的表达与临床病理特征的相关性。方法:免疫组化S-P法检测90例卵巢浆液性和黏液性肿瘤的黏蛋白MUC1的表达。结果:(1)交界性与恶性卵巢肿瘤中黏蛋白MUC1的表达阳性率明显高于良性肿瘤,差异有显著性(P=0.0001);(2)黏蛋白MUC1与WHO病理分级、FIGO临床分期、大网转移显著相关(P<0.05)。结论:粘蛋白MUC1的在恶性卵巢上皮性肿瘤中呈高表达,其表达强度与WHO病理分级、FIGO临床分期、大网转移相关,因此,MUC1的表达可作为卵巢上皮性肿瘤的良、恶性的检测指标。

Objective：To study mucin MUC1 expression and clinical pathological features relationship in serous and mucinous ovarian tumors, iethods：SP immunohistochemistry technique was used to evaluate the expression of mucin MUC1 in 90 cases of serous and mucinous ovarian tumors. Result： （ 1 ） Expression of mucin MUC1 in borderline ovarian tumor and malignant ovarian tumor is significantly higher than that in benign ovarian tumor（ P = 0.0001 ）. （2） Expression of mucin MUC1 was significantly associated with WHO pathological grades, FIGO clinical stage, the greater omental metastasis （P 〈0.05）. Conclusion：The expression of mucin MUC1 in ovarian malignant was high. MUC1 was related with WHO pathological grades, FIGO clinical stage, the greater omental metastasis. Mucin MUC1 is an excellent indicator for benign and malignant tumor in ovarian epithelial tumor.