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二十二碳六烯酸(DHA)复合物对胃腺癌细胞内H-Ras和p16 mRNA含量的影响 被引量：1

Effects of docosahexaenoic acid (DHA) compound on H-Ras and p16 mRNA transcription in gastric adenocarcinoma
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摘要 目的研究DHA复合物抗肿瘤作用机理。方法用RT-PCR法研究DHA复合物对胃腺癌细胞内H-Ras和p16mRNA含量的影响。结果与阴性对照组相比,DHA复合物使胃腺癌细胞内H-RasmRNA含量明显降低(P<0.05),p16mRNA含量明显增加(P<0.05).结论DHA复合物能显著降低H-Ras癌基因的转录,并能显著增加p16押癌基因的转录,从而抑制肿瘤细胞的增殖。 Objective To study the antitumor mechanism of DHA compound. Methods RT-PCR was used to investigate the effects of DHA compound on H-Ras and p16 mRNA transcription in gastric adenocarcinoma. Results Compared with control, the content of H Ras mRNA was decreased and the content of p16 mRNA was increased in gastric adenocarcinoma significantly after treated with DHA compound. Conclusion The transcription of H-Ras gene was decreased and the transcription of p16 gene was increased in gastric adenocarcinoma after treated with DHA compound and thus the cancer cell growth was inhibited.
作者 程东 韩晓英 李慧 赵丽 孙克任
机构地区 山东省疾病预防控制中心 山东师范大学 山东大学
出处 《中国海洋药物》 CAS CSCD 2006年第3期40-42,共3页 Chinese Journal of Marine Drugs
关键词 二十二碳六烯酸 细胞凋亡 H-RAS P16 docosahexaenoic acid（DHA） apoptosis H-Ras p16
分类号 R931.74 [医药卫生—生药学] R979.1 [医药卫生—药品]
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中国海洋药物
2006年 第3期

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