食管癌放疗后复发的再放疗32例疗效观察

Secondary radiotherapy for recurrent esophageal carcinoma after radical radiotherapy in 32 patients

观察根治性放疗后局部复发食管癌患者适形超分割放疗的疗效，分析2000年5月～2005年3月我院收治的32例放疗后局部复发采用适形超分割放疗患者临床及随访资料。CR 19例（59．4％），PR 7例（21．9％），SD 3例（9．3％），PD 3例（9．3％）。6个月、1年、2年和3年生存率分别为65．6％（21／32）、53．3％（16／30）、28、6％（8／28）和14．3％（3／21）。死亡原因：局部失败16例，全身广泛转移8例，食管气管瘘5例。初步研究结果提示，三维适形超分割放疗可作为食管癌根治性放疗后局部复发患者的一种有效治疗手段。

The objective of this study was to investigate therapeutic effects of hyperfracted and 3-dimensional conformal radiotherapy （H-CRT） in recurrent esophageal carcinoma after radical radiotherapy. From May 2000 to March 2005, 32 patients with esophageal carcinoma who developed regional recurrence after radical radiotherapy were analyzed. All patients were given H-CRT. The overall response was 81.3% with CR in 19 patients （59.4%）, PR in 7 patients （21.9%） and SD and PD in 3 patients （9.3%）. The 6 month, 1-, 2-, 3-year survival rates were 65.6% （21/32）, 53.3% （16/30）, 28.6% （8/28） and 14.3% （3/21） respectively. Conclusion： In patients with recurrent esophageal carcinoma after radical radiotherapy, H-CRT is an alternative effective method.