摘要
Objective: presenilin- 2 is one of the causative genes for familial Alzheimer’s disease, and the apolipoprotein E∈ 4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer’s disease. Polymorphism of the regulatory region of presenilin- 2 has recently been reported to be associated with sporadic Alzheimer’s disease in a Russian population. The purpose of this study was to determine whether Alzheimer’s disease is associated with the presenilin- 2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study. Methods: We examined 230 patients with Alzheimer s disease, along with an equal number of age-and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis. Results: The presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer’s disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer’s disease (0.20) and elderly controls (0.20). We found no evidence for an association between the presenilin-2 polymorphism and the apolipoprotein E∈ 4 allele. Conclusions: Our results fail to support an association of presenilin- 2 gene polymorphism with Alzheimer’s disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.
Objective: presenilin- 2 is one of the causative genes for familial Alzheimer's disease, and the apolipoprotein E ∈ 4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of presenilin- 2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the presenilin- 2 gene polymorphism and the apolipoprorein E genotype in an extended case-control study. Methods: We examined 230 patients with Alzheimer's disease, along with an equal number of age-and sex-matched controis from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis. Results: The presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer's disease patients (0. 17) and younger controls (0. 15), and in late-onset Alzheimer's disease (0.20) and elderly controls (0. 20) . We found no evidence for an association between the presenilin-2 polymorphism and the apolipoprotein E ∈ 4 allele. Conclusions: Our results fail to support an association of presenilin -2 gene polymorphism with Alzheimer's disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.
出处
《世界核心医学期刊文摘(神经病学分册)》
2006年第5期55-56,共2页
Digest of the World Core Medical Journals:Clinical Neurology