摘要
为合理利用剑麻皂甙元资源,系统地考察了孕甾-3S,16S,20S-三醇和溴化氢/乙酸溶液的反应,并且发现了孕甾-3S,16S,20S-三醇的区域选择性乙酰化溴代反应,从而为转化孕甾-3S,16S,20S-三醇成为16R-溴代孕甾-3S,20S-二醇二乙酸酯提供了一个有效方法.
In order to make rational utilization of tigogenin, the reaction of pregnane-3S,16S,2OS-triol and HBr/HOAc was explored in detail, and a regioselective acetylation-bromination reaction of pregnane-3S,16S,2OS-triol was found during this exploration. Based on this regioselective acetylation-bromination, pregnane-3S, 16S,20S-triol can be easily transformed into 16R-bromopregnane-3S,2OS-diol diacetate in good yield.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2006年第12期1265-1268,共4页
Acta Chimica Sinica
基金
国家自然科学基金(Nos.29372077
20472052)资助项目.
