碳酸锂联合治疗伴兴奋攻击行为的难治性分裂症的对照研究

The effect of lithium carbonate combining clozapine for the resistant schizophrenics with agitation and aggressive behavior

目的:比较碳酸锂联合氯氮平与单用氯氮平治疗伴兴奋攻击症状的难治性分裂症疗效及安全性。方法:将60例伴兴奋攻击症状的难治性分裂症患者随机分为2组,A组碳酸锂联合氯氮平,B组单用氯氮平。分别在治疗前及治疗后第2、4、68、周末,进行PANSS评定,以PANSS的P4、P7、G8、G14 4条目评定兴奋症状,以S1、S2、S3 3条目评定攻击危险性症状,并在第8周末评定其疗效;用TESS评定不良反应;在治疗前及治疗后第4、8周检查脑电图。结果:兴奋攻击因子评分A组在治疗的第4周末,B组在治疗的第6周末均有明显下降;治疗结束时,A组总体疗效明显高于B组;2组间不良反应无明显差异。结论:碳酸锂联合氯氮平能快速、有效地控制难治性分裂症及其兴奋攻击症状。

Objective： To compare the effect and tolerate of different treating methods for the resistant schizophrenics with agitation and aggressive behavior, these different methods were lithium carbonate combining elozapine and elozapine alone. Mehods：60 resistant schizophrenics with agitation and aggressive behavior were divided into two groups randomly. The patients of A group were treated with lithium carbonate combining elozapine, The patients of B group were treated with elozapine alone. The PANSS was used to rate the patients at the end of week second ,fourth, sixth, eighth. The agitation symptoms were evaluated by P4,P7, G8,G14 in PANSS. The aggressive was evaluated by S1, S2,S3. We rated the side effects by TESS. The EEG was examined at the end of the week fourth and eighth .Resluts： The agitation and aggressive symptoms reduced significantly at the end of the week fourth in A group, the week sixth in B group. At the end of study, the improvement of combining group was significantly higher than the control group and the side effects were not significantly difference . Conclusions： The lithium carbonate combining clozapine was effective for the resistant schizophrenics with agitation and aggressive behavior and can reduced those behavior quickly.