不同病程精神分裂症患者临床对照分析

The controlled analysis of the clinical feature of schizophrenia patients in various course of diseases

目的:探讨不同病程精神分裂症患者临床特征。方法:将203例住院精神分裂症患者按病程分成2组:研究组(病程<5年)133例和对照组(病程≥5年)70例,采用自编《住院精神分裂症患者一般项目调查表》进行统计分析。结果:职业:对照组无业者比例较多见(P<0.05)。文化:研究组初中多见;对照组高中及以上多见,2组比较有显著性差异(P<0.05)。婚姻:对照组离异比例较多见(P<0.05)。研究组病前生活事件、急性或亚急性起病较多见(P<0.05或P<0.01)。研究组关系妄想较多见,对照组自语自笑、阴性症状较多见(P<0.05或P<0.01)。2组间疗效差异不明显,对照组第二代抗精神病药物使用更广泛(P<0.05)。结论:不同病程精神分裂症患者在文化、职业、婚姻、诱因、起病形式、临床表现等方面均有差别。第二代抗精神病药物有助于改善精神分裂症临床疗效。

Objective： To explore the clinical feature of schizophrenia patients in various course of diseases . Methods： 228 schizophrenia in - patients were been divided two groups according to course of diseases： 133 cases had as research group（ course of diseases less than 5 years） and 70 cases had as control group（course of diseases more than 5 years）, Using self-edit 〈 general condition survey inventory of schizophrenia in - patients 〉 , we made statistics and analysis. Results： Occupation： the control group had more unemployed than that of research group（ P 〈0.05）. Education： the research group had more junior high school,the control group had more senior high school or more higher education, compared with the research group, the control group＇ s education had significantly difference（ P 〈 0. 05）. Marriage： the control group had more divorcers（ P 〈 0.05）. Compared with the control group, the research group had more predromal life events, the types of onset were acute or sub - acute, which had significantly difference（ P 〈 0.05 or P 〈 0.01 ）. The symptoms of research group had more delusion of reference, the control group had more speech to themselves or no reasoning laugh, negative symptoms, which had significantly difference（ P 〈 0.05 or P 〈 0.01 ）. The curative effect between two groups had no difference, the control group took the second generation anti - psychosis drugs more extensive , which had significantly difference（ P 〈 0.05）. Conclusions： Schizophrenia patients in various course of diseases had difference education, occupation, marriage, pathogenesis, types of onset and clinical features. The second generation anti - psychosis drugs are good for improving the curative effect of schizophrenia patients.