青少年急性毒鼠强中毒患者心肌酶谱的动态变化

Dynamic Changes of Myocardial Enzyme Spectrum in Teenagers with Acute Tetramine Poisoning

目的:探讨急性毒鼠强中毒青少年患者心肌酶谱(CK、CK-MB、AST、LDH、α-HBDH)的变化规律及与中毒量的关系,为临床诊治提供参考依据。方法:入院当天对18例中毒者进行毒鼠强浓度测定,并分别于2 h及3、5、7、14、21 d抽血进行心肌酶谱测定。结果:毒鼠强中毒患者与正常年龄组相比心肌酶谱大幅升高(P<0.01),且与毒鼠强浓度呈正相关(P<0.01或P<0.05)。结论:毒鼠强中毒患者心肌酶谱的升高与心肌损害和骨骼肌抽搐有关,与毒鼠强的浓度成正比,其升高是可逆的,测定心肌酶谱对病情诊断及预后判断具有重要意义。

Objective ：To investigate the pattern changes in myocardial enzyme spectrum in teenage patients with acute Tetramine （TEM） poisoning and their relationship with plasma TEM concentration. Methods：The plasma TEM of 18 patients were measured on the admission day; the myocardial enzyme spectrum were measured at 2 h,and on 3,5,7,14 and 21 d of the hospitalization. Results：The myocardial enzyme spectrum of the patient group was much higher than that in the normal group （P 〈0.01 ） and it was positively correlated with plasma TEM concentration （P 〈 0.01 or P 〈 0.05）. Conclusion：The rise of myocardial enzyme spectrum was related to the myocardial injury and convulsion of skeletal muscle,and it showed a direct ratio to plasma TEM concentration. Measurement of myocardial enzymes was of significance to diagnosis and accessing the prognosis of the illness.