中西医结合治疗慢性非细菌性前列腺炎的疗效观察

Clinical Effects of Qianlieanshua and Sildenafil in the Treatment of Chronic Non-bacteria Prosta Tiffs and Concomitant Erectile Dysfunction

目的 探讨前列安栓结合西地那非治疗慢性非细菌性前列腺炎（CNP）合并勃起功能障碍（ED）的临床效果。方法CNP合并ED患者69例，随机分为两组，治疗组35例，使用前列安栓4周后加用西地那非治疗。对照组34例持续使用前列安栓8周。分别于4～8周末进行NIH—CPSI评分和IIEF-5评分观察疗效。结果 4周末治疗组和对照组NIH—CPSI分别为（13．1±4．7），（13．3±4．5），较治疗前均显著下降（P〈0．01）两组问比较差异无统计学意义（P〉0．05），两组IIEF-5评分分别为（14．1±3．3）、（14．3±5．0）较治疗前有所上升（P〈0．01），但两组问比较差异无统计学意义（P〉0．05），8周后治疗组NIH—CPSI评分（7．8±2．8）、IIEF-5评分（20．1±4．4）与4周末比较差异均有统计学意义（P〈0．01）；对照组NIH—CPSI评分（12．7±2．3）、IIEF-5评分（14．3±4．5）、与4周末比较差异均无统计学意义（P〉0．05）；两组问NIH—CPSI与IIEF-5评分比较差异均有统计学意义（P〈0．01），治疗组IIEF-5评分值与NIH—CPSI值呈负相关关系。结论 对CNP合并ED患者在使用前列安栓加用西地那非能有效治疗ED，同时使NIH—CPSI评分降低，促进CNP恢复。

Objective To evaluate the effects of Qianlieanshua and sildenafd in the trearment of chronic non - bacteria prostatitis （CNP） with erectile dysfuuction （ED） . Methods Sixty - nine cases diagnosed of CNP with ED were randemized into trial group 35 and control group 34, in trial group were used Qianlieanshua for 4 weeks. Then sildenafd was added for 4weeks, in control group, of Qianlieashua were used for 8 weeks. All the cases were evaluated with N/H - CPSI and IIEF - 5 at 4weeks and 8weeks, respectively, affertreatment. Results At the end of the 4 th weeks. NIH- CPSI score was 13.1± 4.7 in trial group and （13.3±4.5） in control group, which were signifcantly decreased compared with pre - treatment in both groups （ P 〈 0.01 ）, but there was no statistically significant difference betweer the 2 groups （ P 〉 0.05） . IIEF - 5score was （ 14.1± 3.3） in trial group and （ 14.3 ± 5.0） in control group, which were significandy increased compared with pre - treamaent in both groups （ P 〈 0.01 ） . But there was no statisti- cally significant difference between the 2 groups （P 〉 0.05） . At the end of 8 week. NIH- CPSI score was （7.8 ± 2.2） and IIEF- 5 score was （20.1 ±4.4） in trial group which were significandy different from those at the end of 4 th week （P〈0.01） .NIH- CPSI score was （12.7 ± 2.3） and IIEF- 5 score was （14.3 ± 4.5） in control group, which were not significandy different from those at the ead of 4 thweek （ P 〉 0.05） .There were significant differences of NIH - CPSI and HEF - 5 scores between the 2 group （ P 〈 0.01 ） . Thechange of NIH - CPSI score was negatively correlated with that of HEF - 5 in trial group （ r = - 0.89, P 〈 0.01 ） . Conclusion For Patients with CNP with ED were Treated of Qianlieanshua and sildenafil can effectively improve erectile functions as well as decrease the NIH - CPSI score, thus in favor of covering from CNP.