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血吸虫病并结肠癌ING1、p53、bcl-2基因表达的研究 被引量：3

Expression of ING1、p53、bcl-2 in Carcinoma of Colon with Schistosomiasis
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摘要 目的探讨血吸虫病并结肠癌与ING1、p53、bcl-2基因之间的相关性及其可能的作用机制。方法采用免疫组化Envision法检测血吸虫病并结肠癌62例、无血吸虫病56例结肠癌中的ING1、p53、bcl-2的表达。结果在血吸虫病并结肠癌组中的ING1阳性表达率(35.5%)明显低于无血吸虫病结肠癌组(46.4%),结果有统计学意义(P<0.05);而两组中的p53、bcl-2阳性表达率结果无统计学意义(P>0.05)。结论血吸虫病患者的抑癌基因ING1的失活对结肠癌的发生有一定的影响。 Objective To the study relationship between ING1, p53, bcl-2 and colon with schistosemiasis. Methods Envision immunohistochemical method was used to detect the ING1, p53, bcl- 2 expression in 62 cases of carcinoma of colon with schistosemiasis, and 56 cases of carcinoma of colon without schistosemiasis. Results ING1 positivity rate in the two different groups was significant（P 〈 0.05）. However, p53, bcl-2 positivity rate in the two groups was insignificant （P 〉 0.05）. Conelusion Schistosoma japonicum infection affects the expression of ING1 in carcinoma of colon.
作者 吴鸿业 胡乃民 丁厚中 王建良 李海
机构地区 昆山第一人民医院锦溪分院普外科 昆山第一人民医院外科 昆山第一人民医院病理科
出处 《苏州大学学报（医学版）》 CAS 北大核心 2006年第3期375-377,共3页 Suzhou University Journal of Medical Science
基金 江苏省昆山市科技局2005年社会发展计划项目基金资助(No.KS0526)
关键词 血吸虫病 INGI基因 结肠癌 schistosomiasis ING1 carcinoma of colon
分类号 R532.21 [医药卫生—内科学] R735.35 [医药卫生—肿瘤]
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参考文献8

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二级参考文献26

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苏州大学学报（医学版）
2006年 第3期

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