妊娠高血压疾病患者氧化应激状态的改变

Study on Oxidative Stress and Pregnancy Induced Hypertention

目的探讨妊娠高血压疾病患者氧化应激状态的改变情况。方法选取妊娠高血压疾病患者60例,其中妊娠高血压患者15例,轻度子痫前期患者15例,重度子痫前期患者30例。另取同期住院分娩的正常孕妇30例作为对照组。所有研究对象均测血清同型半胱氨酸、丙二醛、超氧化物歧化酶、谷胱甘肽过氧化物酶水平。结果妊娠高血压疾病组MDA水平为7.02±3.05 nmol/L,显著高于对照组5.16±2.79 nmol/L(P<0.01),妊娠高血压疾病组GSH-PX水平105.41±32.95 U/0.1 ml,明显低于对照组127.52±40.64 U/0.1 ml(P<0.05),两组SOD水平无显著差别。妊娠高血压疾病组Hcy为11.8±3.4μmol/L,显著高于对照组9.7±3.0μmol/L(P<0.01)。并且妊娠高血压疾病组Hcy与MDA呈正相关。结论妊娠高血压疾病患者由于氧化物质增加,抗氧化物质减少,氧化还原系统平衡失调,呈现氧化应激状态。

Objective To investigate the relationship between oxidative stress and pregnancy induced hypertention. Methods Ninety pregnant women were recruited. Sixty pregnant women suffering from PIH and the other 30 normal pregnant women were served as the controls. Fasting serum homocysteine（Hcy） was determined in the above two groups, as well as malondialdehyde （MDA）、superoxide dismutases（SOD） and glutathione peroxidase（GSH-PX）. Results Compared these with those in the control group, women in the PIH group had a higher level of Hcy statistically（ P 〈 0.01 ） and MDA（ P 〈 0.01）, the lower level of GSH-PX. However, there was no significant difference in the level of SOD between the two groups. In addition, the level of Hcy had positive relationship with the level of MDA in PIH group. Conclusion PIH can increase oxidant and decrease antioxidant, thus it has positive effect on oxidative stress.