胎盘部位滋养细胞肿瘤的临床病理及免疫组化分析

Clinicopathologic and Immunohistopathologic analyse of Placental Site Trophoblastic Tumor

目的:探讨胎盘部位滋养细胞肿瘤(PSTT)的临床病理及免疫组化特点。方法:收集8例PSTT患者的临床资料,并重新切片行组织学HE染色及SP法免疫组化染色,光镜观察。结果:PSTT是一种继发于妊娠后的妊娠相关疾病,常见症状为闭经及/或阴道流血,血清绒毛膜促性腺激素(HCG)可有轻～中度升高。光镜下瘤细胞为单一种植型的中间型滋养细胞,成片状、条索状浸润于肌纤维之间,血管浸润明显,但少有出血坏死及血管内瘤栓,分裂象少见。免疫组化示上皮膜抗原(EMA)、角蛋白(CK)、人胎盘泌乳素(HPL),中到强阳性表达。HCG仅1例弱阳性表达,肌动蛋白(Act)、波形蛋白(Vim)均阴性表达。结论:PSTT为少见的滋养细胞肿瘤,具有独特的光镜及免疫组化特点,这些特点可与其他滋养细胞疾病鉴别。

Objective To study the elinicopathologie features and immunohistoehemieal of placental site trophoblastic tumor（PSTT）. Methods To collect 8 cases of PSTT and renew dyeing of HE and SP immunohistochemical stain, then studied by microscope. Results PSTT is a kind of desease which was eorreleative with pregency. Change of life and vigina bleeding were quite familiar and also Human chorionic gonadotropin（HCG）of blood serum rose lowly or moderately. Microscopically,tumor was consisted of onefold osculant trophoblastic cells and tomor cells invaded into peripheral muscularis sheetly or stripply with a little bleeding, necrosis and thrombus and seldomto watch karyomitosis, meanwhile tumor infiltrated blood vessel obviously. Immunohistochemieal staining showed thattumor tissue expressed EMA,CK and HPL intensively,only one case expressed HCG faintly Act, Vim were expressed negatively. Conclusion A rare tropho blastic tumor,PSTT has its particular characteristics ferentiate it with other trophoblastic diseases. of microscope and immunohistochemistry and all these can differentiate it with other trophoblastic diseases.