ER与PR等在绝经后子宫内膜息肉中的表达

The Expression of Estrogen Receptors,Progesterone Receptors,BCL-2 and Ki-67 in Postmenopausal Endometrial Polyps

目的:探讨雌激素受体(ER)、孕激素受体(PR)、BCL2、Ki67与绝经后子宫内膜息肉的关系。方法:选择27例绝经后萎缩的子宫内膜作为对照组,33例绝经后子宫内膜息肉样本。所有样本均未进行过激素治疗。用SP免疫组化法检测绝经后子宫内膜息肉和萎缩子宫内膜中ER、PR、BCL2、Ki67的表达。结果:与对照组相比较:息肉的腺上皮和间质细胞中ER、BCL2、Ki67的表达升高(P<0.05);PR在两组中的表达无显著差异(P>0.05)。结论:雌激素受体可能在绝经后子宫内膜息肉的发生中起到一定作用,它可能通过直接刺激局部子宫内膜增生或者抑制凋亡而发挥作用。

Objective To explore the relationship between estrogen receptors（ER）, progesterone receptors（PR）, BCL-2,Ki-67 and postmenopausal endometrial polyps. Methods thirty-three postmenopausal endometrial polyps and twenty-seven postmenopausal endometrium were selected, none sample was using hormonal therapy. The presence of ER,PR, BCL-2, Ki-67 were detected by immunohistochemical staining. Results In both the glandular epithelium and stroma of endometrial polyps,ER,BCL-2 and Ki-67 showed significantly more positive staining than the inactive endometrium from the control group（P〈0.05）. There was no difference in expression of PR between the two groups. Conclusion ER may play a role in the development of postmenopausal endometrial polyps, Which either by direct stimulation of prolifertion or by inhibition of apoptosis.