肺孤立性小结节的良恶性判别相关分析

Differentiate Analysis Benign or Malignant Tumour of Solitary Pulmonary Nodule

目的:对直径≤3cm肺孤立性结节的良恶性判别进行统计学相关分析。方法:根据良恶性两类病例的年龄、性别及其螺旋CT或HRCT征象等14种因素,进行χ2检验,在计算χ2值的基础上计算Pearson列联系数r(又称相关系数)。结果:各种因素中年龄、形态、边缘、分叶、棘状突起、毛刺、血管集束、空泡征及钙化在良、恶性SPN组间有显著差异(P<0.001);年龄、边缘、分叶、棘状突起、毛刺、及空泡征的列联系数>0.5,其中毛刺征的列联系数最大,r值为0.677,关系最密切;性别、SPN位置、胸膜凹陷征、空洞在两组间差异无显著性(P>0.05),其列联系数<0.5,尤其性别的列联系数最小,r值为0.015,与良恶性判别几乎关系。结论:χ2检验只能说明各种因素间有无相关关系,列联系数r说明各种因素间相关的密切程度。在良恶性SPN组间作相关判别,列联系数比χ2检验更具有统计学意义,对鉴别诊断起重要作用。

Objective To differentiate analysis benign or malignant tumour of Solitary pulmonary nodule （Diameter ≤3cm） （SPN） in Statistics. Methods According to the age, sex, and the CT or HRCT appearances etc factors of these two diseases, were under way in Chi-Square Test and Relation-Coefficient. Results The differentiation was much correlated with the age, shape, verge, lobalation, spinous process, spieulation, convergence, vacuole and calcium in benign or malignant tumour of SPN（P〈0. 001）. The number of Relation-Coefficient with the age, verge, lobalation, spinous process,spiculation and vacuole was 2〉 0.5. The Relation-Coefficient was the biggest of spiculation （r=0. 677）, The relation of those was the closest. The differentiation was seldom correlated with sex, place, pleural indentation and cavity（P〉0. 05） ,which the number of Relation-Coefficient〈0.5. Sex of the Relation-Coefficient was the smallest （r=0. 015）, sex had nothing to do with differentiate analysis benign or malignant tumour of SPN. Conclusion Chi Square Test only showed to have something or nothing to do with the factors, and the Relation-Coefficient showed some degree with the relation. The Relation-Coefficient was higher significance than Chi-Square Test in statistics to differentiate analysis benign or malignant tumour of SPN. It is very valuable for discriminate diagnosis.