VEGF在非小细胞肺癌中的表达及对预后的影响

Expressions of VEGF in Non-small Cell Lung Cancer and Their Correlation with Prognosis

目的:研究非小细胞肺癌(NSCLC)组织中血管内皮因子(VEGF)的表达及其对预后的影响。方法:应用免疫组化SP法检测肺癌、癌旁及肺良性瘤样病变组织中VEGF的表达。结果:肺癌、癌旁及肺良性瘤样病变组织中VEGF的表达率为74.8%、46.3%和18.1%(P<0.05),VEGF阳性组术后生存明显短于阴性组(P<0.05)。VEGF的表达与年龄、性别、吸烟、癌组织类型、分化程度和不同临床分期均无明显关系(P>0.05),但与淋巴结转移有相关性(P<0.05)。结论:VEGF在肺癌组织中异常表达,且其表达与肺癌患者的预后有关,是判断预后的良好指标,可能成为非小细胞肺癌新的诊断标志及基因治疗的新靶点。

Objective To study the expressions of VEGF in non-small cell lung cancer（NSCLC）and their correlation with prognosis. Methods Expressions of VEGF were detected by streptavidin-peroxidase（S-P）method in NSCLC, adja cent tumor tissues andbenign lesions. Results The expression rate of VEGF in NSCLC,adjacent tumor tissues andbenign lesions were 74.8%,46. 3% and 18.1% （P〈0.05）. The survival of of NSCLC was associated with expressions of VEGF. There was no relationship between VEGF and age, sex, cigarette smoking, histologic subtype, differentiation and TNM stages（P〉0.05）, but lymph node metastases（P〈0.05）.Conclusion VEGF was overexpressed in NSCLC and VEGF expressions were related with prognosis. VEGF can be a good indication in the diagnosis of prognosis. It may be identified as a defining diagnostic marker and a potential therapeutic target in NSCLC.