肺癌相关肿瘤标志物的研究进展

The study of tumor biomarkers associated with lung cancer in diagnosis

肺癌相关肿瘤标志物是肺癌组织和细胞由于癌基因及其产物的异常表达所产生的抗原和生物活性物质,包括蛋白质、酶、激素、癌基因产物等。近年来肿瘤标志物成为肿瘤基础和临床应用的一个十分活跃的领域。其对肺癌的辅助诊断、判别类型、估计预后、评价疗效、定位诊断、靶向治疗等均具有重要指导意义。对癌胚抗原、神经元特性烯醇化酶、细胞角蛋白19片段、血管内皮生长因子、增生细胞核抗原、表皮生长因子受体等肺癌相关肿瘤生物标志物的研究进展进行阐述。

Tumor biomarkers are bioactive substance and antigen produced by lung cancer tissue and cell because of oncogene abnormal expression including protien, enzyme and hormone et al. In recent years, tumor biomarker has been one of the most active areas in basic research and clinical investigation of oncology. A variety of tumor biomarkers have been shown to have potential applications in accessory diagnosis, clinical typing, prognosis, and therapeutic response amd target therapy of lung cancer. In this review, we will discuss about a dozen of tumor biomarkers associated with lung cancer, including CEA, NSE, CYFRA21-1, PCNA, VEGF, EGFR and LTA.