摘要
目的:探讨谷胱甘肽转移酶(GSTπ)和拓扑异构酶(TopoⅡα)在乳腺癌组织中表达状况及意义。方法:取乳腺癌标本72例,乳腺腺瘤30例,利用SP免疫组织化学方法,检测GSTπ和TopoⅡα阳性率。结果:GSTπ在乳腺腺瘤中阳性率为26.67%,在乳癌中阳性率为68.05%。TopoⅡα在腺瘤和腺癌中阳性率分别为0.00%和50.00%。Ⅲ级乳癌中GSTπ表达率明显高于Ⅰ、Ⅱ级;TopoⅡα则在乳癌Ⅰ级中表达高于Ⅲ级。结论:GSTπ和TopoⅡα在乳癌中阳性率明显高于腺瘤。检测GSTπ和TopoⅡα对乳腺癌化疗药物的选择有指导作用。
Objective： To investigate the expression of GSTπ and Topo Ⅱα. in breast cancer and its clinical significance. Methods： 72 cases with breast cancer and 30cases with adenoma were stained immunohistochemically for GSTπ and TopoⅡα. positive rate. Results： The positive rate of GST.was 26. 67 % （6/30） in adenoma of breast and that in breast cancer was 68.05% （49/72）. The expression of Topo Ⅱα in breast cancer was 50. 00% （36/72）, and that in adenoma of breast was 0. 00% （0/30）. The expression of GST.in clinical stagem was higher than that in stage Ⅰ , Ⅱ （P〈0.05）. The expression of TopoⅡα .in clinical stage Ⅰ was higher than that in stagem （P〈0. 05）. Conclusion：The expressions of GSTπ and Topo Ⅱα. in breat cancer were higher than that in adenoma of breast. Analysing the expressions of GSTπ and Topo Ⅱα .in breat cancer may have direction in selecting the drug in chemotherapy
出处
《河北北方学院学报（医学版）》
2006年第3期7-9,共3页
Journal of Hebei North University:Medical Edition
