腹腔镜胆囊切除术患者围手术期外周血中IL-6、TNF-α的变化

The Changes of IL-6 and TNF-α in Peripheral Venous Blood of Laparoscopic Cholecystectomy Patients before and after Operation

目的：观察腹腔镜胆囊切除术患者围手术期外周血中IL-6、TNF-α的变化，探讨其临床意义。方法：选择20例ASAⅠ～Ⅱ级择期行腹腔镜胆囊切除术患者（LC组），观察其术前、术后第1天、术后第3天的外周血IL-6、TNF-α的变化，并与同期20例传统开腹胆囊切除术患者（OC组）进行对比。结果：两组患者术后第1天IL-6、TNF-α较术前升高（P〈0．05），但组间比较差异无显著性（P〉0．05）。术后第3天LC患者IL-6、TNF-α基本上恢复至术前水平，而OC组患者IL-6、TNF-α高于术前，组间比较差异有显著性（P〈0．01）。LC组住院天数明显缩短。结论：与OC组相比，LC组患者对机体的炎症反应和免疫功能影响轻且恢复快。

Objective： To compare the effects of laparoscopic cholecysteetomy （LC）and open choleeystectomy （OC）on interleukin-6 （IL-6）and tumour necrosis factor- alpha（TNF-α）in Peripheral venous blood. Methods： Twenty ASA Ⅰ～Ⅱ patients, aged 35-55yrs,weighing 47-70kg, who had experienced laparoscopic cholecysteetomy （LC）were studied. Another 20 patients aged 33-58yrs,weighing 50-72kg, who had experienced open cholecystectomy （OC）served as control. Peripheral venous blood samples were taken before operation and on the 1st and 3rd postoperation for determination of IL-6,TNF-α concentrations （ELISA）. Resuits： IL-6,TNF-α levels were significantly increased on the 1st postoperative day compared with the baseline values before operation in both groups but there was no significant difference between the two groups. On the 3rd postoperation IL-6,TNF-α levels returned to preoperative level in group LC while in group OC IL-6,TNF- α levels remained high. Conclusion.. The results showed LC exerts less effects on inflammatory reaction and immune function than that of OC.