奥扎格雷钠联合黄芪注射液治疗糖尿病肾病的疗效观察

Clinical Observation on the Treatment for Early Diabetic Nephropathy by Aozhagelei Injection Combined with Milkvetch Injection

目的:观察奥扎格雷钠与黄芪注射液联合治疗糖尿病肾病的疗效。方法:将84例早期糖尿病肾病患者随机分为3组,每组28例,在常规治疗的基础上,A组加用黄芪注射液,B组加用奥扎格雷钠注射液,C组加用黄芪注射液与奥扎格雷钠注射液,疗程均为20d。观察治疗前后各组尿白蛋白排泄率(UAER),血尿素氮(BUN),血清肌酐(SCr),糖化血红蛋白(HbAlc)的变化。结果:糖化血红蛋白,血清肌酐,血尿素氮,尿白蛋白排泄率:3组治疗后均比治疗前显著下降(P<0.01),C组下降幅度优于A组和B组(P<0.05)。结论:奥扎格雷钠联合黄芪注射液治疗糖尿病肾病能降低糖化血红蛋白,显著降低尿白蛋白排泄率,同时改善肾功能。

Objective： To investigate the therapeutic effect of mickvetch injection（MI） combined with Aozhagelei injection on earlydiabetic nephropathy（EDN）. Methods： 84 patients with EDN were randomly divided into three groups, with 28 in each groups. After conventional hypoglycemic therapy for the patients in all groups, patients in group A were treated with MI, for group B with Aozhagelei injection and group C with Aozhagelei plus MI respectively. The therapeutic course for all patients was 3 weeks. The related indices of EDN before and after treatment were determined and compared, including blood urea nitrogen（BUN）, Serum creatinine （SCr）, urinary albumin excretion rates（UAER） and, HbAIc. Results： the levels of BUN, SCr, H bAIc, and UAER were significantly decreased in all 3groups（ P〈 0. 01）. and the decreasement in Group C was more significant than that of the other two groups （P〈0. 05）. Conclution： Aozhagelei injection combined with MI can decrease HbAIc, and UAER significantly in treating EDN and can improve kidney function.