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碱基序列直接测序基础上的HLA-DNA分型方法的研究进展 被引量:1

Research progress of HLA-DNA typing method based on sequence based typing
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摘要 20世纪90年代以来DNA扩增、DNA纯化和人类基因成果对HLA领域的渗透,使得碱基序列测序方法(sequencebasedtyping,SBT)成为一种可直接阅读HLA系统复杂性的基因物质的最佳技术,并在器官移植、人类遗传学、疾病关联等研究方面被认为是HLA基因分析的金标准。就近年来SBT对HLA-DNA分型及其意义的研究进展作一综述。 Sequence based typing (SBT) becomes the best method of HLA typing because of development of DNA amplification, DNA purification and other technology, from 1 990 s, SBT is gold standard of HLA gene typing on organ transplantation, human genetics and disease association.
作者 黄飞 肖露露
出处 《白血病.淋巴瘤》 CAS 2006年第3期229-231,共3页 Journal of Leukemia & Lymphoma
基金 广东省科技厅团队攻关课题资助项目(2003-23003)
关键词 碱基序列直接测序 HLA—DNA分型 DNA扩增 DNA纯化 Sequence based typing HLA typing DNA amplification DNA purification
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