当归肉桂配伍后阿魏酸生物利用度的研究

Study on relative bioavailability of ferulic acid of combination Radix Angelicae Sinensis and Cortex Cinnamomi in mice

目的：研究温里药肉桂与活血药当归配伍后,对当归效应成分阿魏酸生物利用度的影响,探讨活血温里复方的药物配伍机制.方法：将肉桂与当归配伍后灌胃小鼠,采用RP-HPLC测定小鼠血浆中阿魏酸的血药浓度,以单用当归为对照,计算复方中阿魏酸的相对生物利用度.结果：阿魏酸在小鼠体内的药代学过程符合一室模型,肉桂与当归配伍后,当归肉桂复方中阿魏酸的平均相对生物利用度为226.75%.肉桂复方与单药当归的Cmax,AUC0～∞存在差异,而tmax无差异.结论：温里药肉桂与活血药当归配伍,能提高当归主要效应成分阿魏酸的生物利用度,从复方效应成分生物利用度的角度揭示了活血温里复方配伍的科学内涵.

Objective： To study the pharmcokinefics and relative bioavailability of combination Radix Angelicae Sinensis and Cortex Cinnamomi. Method： The content of fendic acid in plasma was determined directly by HPLC after oral administration of Cortex Cinmmomi in combination individually with Radix Angelicae Sinensis. The plasma concentration-time curve were plotted. The main pharmacokinetic parameters and relative bioavailahility were obtained.Result： The plasma concentration-time curve of ferulic aclid conformed to one-compartment model.The relalive bioavailability of Cortex Cinnamomi combined with Radix Angelicae Sinensis were 226.75%. Conclusion： By the statistical analysis, Cortex Cinnamomi combined with Radix Angelicae Sinensis can increase the relative bioavailability of femlic acid.