橙皮苷及铜配合物的抑菌抗氧化活性研究

Study on the antimicrobial and antioxidant activities of hesperidin and the complexation with copper(Ⅱ)

橙皮苷-Cu(Ⅱ)配合物属于新的物质,用牛津杯法研究了橙皮苷及其配合物对大肠杆菌、枯草芽孢杆菌、金黄色葡萄球菌的抑菌活性,橙皮苷-Cu(Ⅱ)配合物对3种菌的最低抑菌浓度,以及不用pH值对配合物抑菌效果的影响。另外,还研究了橙皮苷及其配合物对.OH的清除效应。结果发现橙皮苷-Cu(Ⅱ)配合物的抑菌活性强于橙皮苷,而对.OH的清除作用则不如橙皮苷。

Hesperidin is a new product. The antimicrobial activities of hesperidin and its derivatives were tested against E. coli, St. aureus and B. Subtilis by means of oxford-cup tests. Also the minimum inhibition concectration （MIC）, the antimicrobial effects of Hesperidin with Copper（ Ⅱ） on different pH were discussed. In addition the effects of hesperidin and its complexation on scavenging hydroxyl radicals were studied. The results indicate that antimicrobial activities of hesperidin-Cu（ Ⅱ ） are better than hesperidin, but its effects scavenging hydroxyl radicals are not better than hesperidin.