多巴胺联合甲磺酸酚安妥拉明预防新生儿窒息致持续肺动脉高压的临床研究

Dopamine and phentolamine therapy in the prevention of persistent pulmonary hypertension in patients with neonatal asphyxia.

目的 观察多巴胺联合甲磺酸酚安妥拉明（商品名：立其丁）预防新生儿窒息复苏后持续肺动脉高压的临床疗效。方法 我院2003年1月至2005年12月收治的新生儿窒息82例，入院时随机分成治疗组和对照组，并立即抽血检查血气分析，对照组给予常规治疗，治疗组在此基础上，给予多巴胺3—5μg／（kg·min）、立其丁1-2μg/（kg·min），治疗24h后复查血气分析。结果治疗组持续肺动脉高压（PPHN）的发生率及死亡率明显低于对照组（P＜0．05）。治疗组血气分析结果明显优于治疗前（P＜0．01）和对照组（P＜0．05）。结论多巴胺联合立其丁预防新生儿窒息复苏后持续肺动脉高压有良好的疗效，值得临床推广。

Objective To investigate the results of dopamine and phentolamine in the prevention of persistent puhnonary hypertension （PPH） after resuscitation in patients with neonatal asphyxia. Methods From January 2003 to December 2005, 82 patients with neonatal asphyxia were randomly assigned to receive conventional therapy（ the control group） or dopamine （3 - 5μg/kg/min） plus phentolamine （1- 2 μg/kg/min） in addition to conventional therapy（the treatment group）, blood gas analysis was tested at baseline and at 24 hours after treatment, Results The morbidity and mortality of PPH were significantly lower in the treatment group than those in the control group （ P〈 0.05 ）. The results of blood gas analysis were significantly improved in the treatment group patients as compared witt, their baseline values （ P 〈0.01 ） and those of control group patients （ P 〈0.05 ）. Conclusion Dopamine and phentolamine has favourable results in the prevention of PPH after resuscitation in patients with neonatal asphyxia and is worth recommendation.