三通法针刺对急性缺血性脑血管病患者血清TNF-α及IL-1β的影响

Effects of "Three Ways" Method of Acupuncture on Serum Levels of Tumor Necrosis Factor-αand Interleukin-1βin Patients with Acute Ischemic Cerebrovascular Diseases.

目的观察三通法针刺对急性缺血性脑血管病患者血清TNF-α、IL-1β含量的影响,并探讨其可能的作用机理。方法将60例急性脑梗塞患者,随机分成两组,三通组采用三通法治疗,手足针组采用针刺手足穴位治疗。采用放射免疫法(RIA)检测治疗前和治疗后第6、12和28天TNF-α、IL-1β含量,同时观察比较针刺治疗前后神经功能缺损评分及Barthel指数评分。结果治疗后三通组、手足针组血清TNF-α、IL- 1β含量水平均呈下降趋势(P<0．05);治疗后28天三通组与手足针组血清TNF-α、IL-1β含量接近健康人组水平;三通组与手足针组比较,TNF-α、IL-1β含量水平下降趋势更明显(P<0．05)。与手足针组比较,三通组可明显降低患者神经功能缺损评分、提高患者Barthel指数评分(P<0．05)。结论三通组可降低血清TNF-α、IL-1β含量水平,减轻神经功能受损程度以及提高患者日常生活能力,作用优于手足针组。

Objective To observe the effect of ＂Three ways＂ method of acupuncture on serum levels of tumor necrosis factor-α （TNF-α） and interleukin-1β （IL-1β） in patients with acute ischemic cerebrovascular diseases （ICVD）. Methods Sixty patients with acute cerebral infarction were randomly divided into the treated group treated by ＂Three ways＂ method of acupuncture and the control group by hand and foot acupuncture on acupoints of the hands and feet. Serum levels of TNF-α and IL-1β were detected with radioimmunoassay before treatment and at the 6th, 12th and 28th days of treatment. Neurological deficit score （NDS） and Barthel Index （BI） were also observed in the same time. Results After treatment, serum levels of TNF-α and IL-1β in both groups decreased significantly （P〈 0.05）, approaching the normal range at the 28th day of treatment, which were even lower in the treated group than those in the control group, and the decreasing trend were significantly different （P〈0.05）. Compared with the control group, the effect in decreasing NDS and increasing BI in the treated group was better than that in the control group （P 〈 0.05）. Conclusion ＂Three ways＂ method of acupuncture could reduce serum levels of TNF-α and IL-1β, alleviate injury of nervous function so as to improve the daily life ability, superior to hand and foot acupuncture.