利用多中心合成方法同步合成含N-取代甘氨酸的类肽化合物(英文)

Simultaneous Synthesis of Peptoid Containing N-Substituted-glycines Using the Multipin Method

N-取代甘氨酸聚合体是一类新的聚合体化合物,同多肽相比,N-取代甘氨酸聚合体具有抗酶解稳定性,同时使用市售的伯胺作为构建单元(building block)大大地扩展了天然多肽分子结构的多样性,本文报道了利用多中心多肽合成方法合成了九个含N-取代甘氨酸聚合体多肽杂合休,由于此类聚合体具有抗酶的能力,因此可用于蛋白酶抑制剂的研究。

Peptoid Containing N - Substituted - glycines, or oligo - N - substituted glycines (NSGs) peptide are a new class of polymeric compounds. Compared with peptides, oligo - N -substituted glycines(NSGs) peptide are stable to enzymatic hydrolysis. At the same time,oligo- N -substituted glycines (NSGs) peptide also extended the structural diversities of natural peptides by using a variety of primary amines as building - blocks which are readily available from commercial sources. Here we report that nine oligo - N - substituted glycines (NSGs) peptides were successfully synthesized with the multipin method. Due to their excellent enzyme resistance, these compounds could become useful protease inhibitors.