通心络胶囊与硫氮唑酮治疗心脏X综合征的对比研究

The Comparied Study on the Therapeutic Effect of Tongxinluo and Diltiazem in Patients with X-syndrome

目的:比较通心络胶囊与硫氮唑酮治疗心脏X综合征的临床疗效。方法:入选2002年1月至2005年5月诊断及治疗的心脏X综合征患者60例,随机分为通心络组(30例)及硫氮唑酮组(30例)。评价治疗半年后症状及运动试验结果改善情况。结果:(1)通心络治疗组比硫氮唑酮治疗组显效及有效的人数更多,总有效率明显较高(P<0．05)。(2)通心络组、硫氮唑酮患者治疗后与治疗前比运动时间明显延长(P<0．05),运动ST段压低>0．1mv的持续时间明显缩短(P<0.05),通心络组缩短更明显(P<0．05)。结论:通心络胶囊的治疗明显缓解了心脏X综合征患者的临床症状,提高了患者的运动耐力,缩短了运动时的心肌缺血时间。疗效优于钙通道阻断剂硫氮唑酮。

Objective： To evaluate the therapeutic effect of tongxinluo, a Chinese medicine, in comparison of dihiazem in patients with X - syndrome.Methods： 60 patients with X- syndrome from January 2002 to May 2005 were diveded into two groupa： 30 patients treated with tongxinluo and thirty patients treated with diltiazem. After half a year the improvement of symptom and stress test＇ s result were evaluated.Results： （1） Total effective rate was higher in tongxiuluo group compared with diltiazem group（P 〈 0.05） . （ 2）The movement time after the treatment was significantly longer than before the treatment in tongxinluo group and in diltiazem group （ P 〈 0.05）. The persistence time of ST - segment depression more than 0.1 mv after the treatment was obviously shorter than before the treatment in tongxinluo group and in diltiazem group（ P 〈 0.05）. But the decurtstions of persistence time of ST - segment depression more than 0. 1mv after the treatment in tongxinluo group was more obvious than in diltiazem group（P 〈 0.05） . Conclusion： Tongxinluo can relief clinical symptom, improve exercise tolerance and shorten time of myocardial ischemia in the patients with X - syndrome obviously. The therapeutic effect of tongxinluo surpass that of diltiazem in patients with X - syndrome.