非酒精性脂肪肝与胰岛素抵抗的关系

The relationship between non-alcoholic fatty liver disease and insulin resistance

探讨非酒精性脂肪肝(NAFL)发病与胰岛素抵抗的关系。对63例受检者用放免法测定血清胰岛素,稳态模型法计算胰岛素抵抗指数。同时选择20例无脂肪肝肥胖者作为对照组。脂肪肝组与对照组比较,血清胰岛素、胰岛素抵抗指数显著性增高(P<0.001),重度脂肪肝与中度脂肪肝、轻度脂肪肝比较,血清胰岛素、胰岛素抵抗指数也存在明显增高(P<0.05)。胰岛素抵抗可能系脂肪肝发病的原发因素,而非继发性改变。

To study the relationship between non -alcoholic fatty liver disease and insulin resistance. 63 non -alcoholic fatty liver disease patients（ male 35, femal 28） and 20 obesity without fatty liver disease were selected. Fasting serum insulin levels was measured by radio -immunoassay, insulin resistance index was estimated by the homeostasis model assessment （HOMA -IR）. Compared to controlgroup, patients with non -alcoholic fatty liver disease were characterized by hyperinsluinemia, elevated insulin resistance index （P 〈 0.01 ）. Serum insulin and insulin resistance index were higher in heavy fatty liver disease patients than medium and light patients （ P 〈 0.05 ）. In the pathogeneses of non - alcoholic fatty liver disease, insulin resistance was an original factor probably and not a following changing.