氨溴索治疗分泌性中耳炎55例的近期疗效

Short-term curative effect of ambroxol in treating 55 patients with secretory otitis media

目的：观察氨溴索治疗分泌性中耳炎的疗效。方法：114例(121耳)分泌性中耳炎病人分成氨溴索和糜蛋白酶组。氨溴索组55例(55耳),予氨溴索注射液2 mL(15 mg)作鼓室内注射。糜蛋白酶组59例(66耳),予氯化钠注射液2 mL加糜蛋白酶5 mg作鼓室内注射。1 wk后观察2组疗效及不良反应。结果：1 wk后,氨溴索组有效率89%,糜蛋白酶组64%,2组疗效差异有非常显著意义(P＜0.01)。氨溴索组未见不良反应。结论：氨溴索治疗分泌性中耳炎近期疗效佳,安全性好。

AIM： To observe the curative effect of ambroxol in treating secretory otitis media. METHODS： One hundred and fourteen patients （121 ears） were divided into two groups. Fifty-five （55 ears） patients in the ambroxol group received individually ambroxol injection （2 mL ： 15 mg） in tympanum, while 59 patients （66 ears） in the chymotrypsin group were injected individually with sodium chloride injection 2 mL and chymotrypsin （4 000 U） in tympanum. The clinical effects of both groups were observed 1 wk after the injection. RESULTS： The clinical effective rate of ambroxol group was 89 % 1 wk later, while that of the chymotrypsin group was 64 %; showing significant difference between the two groups （P 〈 0.01）. No adverse reaction occurred in the ambroxol group. CONCLUSION： Ambroxol is an effective and safe medicine in treating secretory otitis media.