硼替佐米在恶性血液病中的作用机制

Mechanisms of bortezomib in hematologic malignancies

硼替佐米作为一种蛋白酶抑制剂,对多发性骨髓瘤细胞表现出抑制细胞生长、诱导肿瘤细胞凋亡、抑制细胞粘附、抑制肿瘤血管生成等作用,同时对血液系统其他恶性肿瘤具有显著的作用。本文就硼替佐米在恶性血液病中的作用机制作一综述。

As a proteasome inhibitor, bortezomib has shown inhibition on cell proliferation, inducing cell apoptosis, inhibition of cell adhension and inhibition of tumor angiogenesis for multiple myeloma cells. Moreover, the significant effects in other hematologic malignancies and the mechanisms of bortezomib in hematologic malignancies are reviewed in this paper.