注射用血凝酶在肝脏围术期的应用观察

Observation on Use of Reptilase at Hepatic Perioperative Stage

目的观察注射用血凝酶在肝脏围术期的止血效果。方法将49例需手术治疗的肝病患者随机分成观察组(27例)与对照组(22例),观察组术前、术后给予注射用血凝酶,对照组术中、术后仅给予常规止血药,比较2组术中出血量、术后静脉血D-二聚体、血性引流液量的变化。结果观察组与对照组的术中出血量分别为(327.1±29.5)、(542.6±30.2)ml(P<0.05),术后静脉血D-二聚体分别为(0.6777±0.053)、(0.9901±0.051)ng/L(P<0.05),血性引流液量分别为(297±27)、(521±22)ml(P<0.05)。结论注射用血凝酶在肝脏围术期的止血作用明显优于常规止血药。

OBJECTIVE：To study the hemostatic effect of reptilase in hepatic perioperative period.METHODS：The study was conducted in 49 patients randomly divided into 2 groups： reptilase group（n = 27） and control group（n = 22） . In reptilase group, the reptilase was given in preoperative, postoperative and intraoperative period;while in control group, other commonly used hemostatics were given in the same way as in reptilase group.Then, the amount of bleeding, the content of D- Dimer in venous blood,and the quantity of postoperative bloody drainage were compared between the 2 groups. RESULTS：Respectively in reptilase and control group, the amount of i ntraoperative bleeding were（327.1 ± 29.5）ml and （542.6± 30.2）ml（P〈 0.05）; postoperative content of D-Dimer in venous blood were（0.6 777± 0.053）ng/L and（0.9 901 ± 0.051）ng/L（P〈0.05）;and the quantity of bloody drainage were （ 297 ± 27） ml and （ 521 ± 22） ml （ P 〈 0.05）. CONCLUSION： The hemostatic effect of reptilase in hepatitis operations is obviously better than that of other commonly used hemostatics.