期刊文献+

胃癌患者术前血浆可溶性P2-选择素和唾液酸水平的变化 被引量:1

下载PDF
导出
摘要 目的:探讨胃癌患者术前检测血浆可溶性P2-选择素(sP2-selectin)和唾液酸水平的临床意义。方法:采用ELISA法、酶偶联法及比色法分别检测117例术前胃癌患者、45例良性胃部疾病患者及40例正常人血浆中sP2-selectin和总唾液酸(TSA)及脂结合唾液酸(LSA)水平并进行比较分析。结果:胃癌患者术前血浆中sP2-selectin、TSA及LSA含量显著高于良性胃部疾病患者及正常人(P<0.01或P<0.05),阳性率分别为72.6%、75.2%和66.7%,血浆sP2-selectin、TSA和LSA水平与临床分期有关(P<0.05),sP2-selectin和LSA水平与胃癌的转移有关(P<0.05)。结论:术前血浆sP2-selectin、TSA及LSA检测对胃癌的临床诊断及预后判断有一定的价值。
出处 《广西医科大学学报》 CAS 北大核心 2006年第2期260-262,共3页 Journal of Guangxi Medical University
  • 相关文献

参考文献8

  • 1Graff J,Klinkhardt U,Schini-Kerth VB,et al. Close relationship between the platelet activation marker CD62p and the granular release of platelet derived factor. J pharmacol Exp Ther, 2002,300 (3) : 952-957.
  • 2Blann AD,Gurney D, Wadley M, et al. Increased soluble P-selectin in patients with haematological and breast cancer:A comparison with fibrinogen,plasminogen activator inhibitor and von W illebrand factor . Blood Coagul F ibrinolysis,2001,12(1) :43-50.
  • 3余耀,周信达,刘银坤.P-选择素及其配体与肿瘤转移关系的研究进展[J].中国癌症杂志,2000,10(5):443-445. 被引量:2
  • 4Borsig L. Selectins facilitate carcinoma metastasis and heparin can prevent them. News physiol Sci, 2004, 19(1):16-21.
  • 5万厚民,李玉民,石淑琴,罗晓梅.胃癌患者血浆可溶性P-选择素及血清唾液酸的变化[J].第四军医大学学报,2002,23(9):838-840. 被引量:2
  • 6Varki A, Varki NM. P-selectin carcinoma metastasis and heparin: Novel mechanistic connection with therapeutic implication. Braz J Medbiol Res, 2001,34 ( 6 ) : 711-717.
  • 7Umihiro T, Yosuke O,Tatsuo N,et al. Prognostic significance of polysialic acid expression in rescued non-small cell lung cancer . Cancer Res,2001,61:1666-1670.
  • 8杨红,吕灿群.胃癌患者血浆缩醛磷脂和糖脂水平变化[J].中国病理生理杂志,2003,19(8):1033-1033. 被引量:2

二级参考文献10

  • 1吕灿群,蔡镇潮.缩醛磷脂的生物学作用及其代谢[J].生命的化学,1994,14(6):33-34. 被引量:8
  • 2Dueck DA, Cham M, Choy PC. The modulation of choline phospho- glyceride metabolism in human colon cancer[J].Mol Cell Biochem, 1996,162(2) : 97 - 103.
  • 3Lee TC. Biosynthesis and possible biological function of plasma- logens[J]. Biochim Biophys Acta, 1998, 1394(2 -3) :129- 145.
  • 4Merchant TE, Minsky BD, l.auwers GY. Esophageal cancer phospholipids correlated with histopathologic findings: a ^31P NMR study[J]. NMR Biomed, 1999,12(4) : 184 - lSS.
  • 5CR McMaster,Lu CQ. The existence of a soluble plasmalo -genase in guinen pig tissues[J]. Lipids, 1992,27(12) :945 -950.
  • 6Morita H, Nakanishi K, Dohi T. Phospholipid turnover in the inflamed intestinal mucosa: arachidonic acid - rich phosphafidyt/plasmenylethano- lamine in the mucosa in inflammatory bowel disease[J]. J Gastroenterol, 1999, 34( 1 ) : 46 -53.
  • 7Can Qun Lu,Jun Lu,Bo Liang Wang,Yao Zong Cui. Changes in ganglioside contents, plasma sialic acid and cAMP levels in experimental hepatoma in mice[J] 2000,Molecular and Cellular Biochemistry(1-2):29~33
  • 8周同,李晓,陈金联,吴云林,王瑞年,楼鼎秀,董德长.粘附分子P选择素在胃癌与肾癌中的表达及意义[J].中华医学杂志,1997,77(7):530-531. 被引量:15
  • 9陈金联,章月星,储榆德,周同,许惠敏,李明烈.选择素单抗对裸鼠胃癌转移抑制的研究[J].上海第二医科大学学报,1998,18(1):30-32. 被引量:8
  • 10张培彤,裴迎霞,朴炳奎,孙桂芝,林红生,祁鑫.肿瘤患者与正常人血小板表面粘附蛋白表达异同的临床观察及意义[J].中华肿瘤杂志,1998,20(3):207-209. 被引量:66

共引文献3

同被引文献6

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部