急性冠状动脉综合征患者血清可溶性细胞间粘附分子水平变化及其意义

Levels and significance of serum soluble cell adhesion molecules in acute coronary syndrome.

目的探讨血清细胞间粘附分子(CAMs)在急性冠状动脉综合征(ACS)发生发展过程中的作用。方法用双抗体酶联免疫吸附法测定40例ACS患者及40例健康体检者血清可溶性细胞间粘附分子-1(sICAM-1)、血管细胞粘附分子-1(sVCAM-1)、E-选择素(sE-S)的浓度。结果ACS组血清sICAM-1、sVCAM-1及sE-S的浓度分别为(371.78±66.78)μg/L、(644.91±169.73)μg/L及(46.14±10.14)μg/L,明显高于正常对照组的(236.45±47.55)μg/L、(342.16±84.16)μg/L及(31.30±5.40)μg/L(P<0.05或P<0.01)。结论CAMs参与了ACS的发病过程。

Objective To discover the role of serum soluble cell adhesion molecules （ CAMs ） in the pathogenesis of the acute coronary syndrome （ACS ）. Methods Serum soluble intercellular adhesion molecule-1（sICAM-1 ） ,soluble vascular cell adhesion molecule-1 （ sVCAM-1 ） and soluble E-selectin（ sE-S） from 40 acute coronary syndrome patients and 40 healthy people were measured by ELISA. Results The concentration of serum sICAM-1 （ 371.78 ± 66.78 ） μg/L,sVCAM-1 （ 644.91 ± 169.73 ） μg/L and sE-S （ 46.14 ± 10. 14 ） μg/L were significandy higher than that of control group [ （ 236.45 ± 47.55 ） μg/L, （ 342. 16 ± 84. 16 ）μg/L and （ 31.30 ± 5.40 ）μg/L （ P 〈 0.05 or P 〈 0.01 ） ]. Conclusion CAMs might play an important role in the pathogenesis of acute coronary syndrome.