期刊文献+

细胞凋亡的分子功能显像 被引量:5

Molecular function imaging of cell apoptosis
下载PDF
导出
摘要 细胞凋亡(cell apoptosis),又称为程序性细胞死亡(programmed cell death,PCD),是一种由多种基因调控的主动性细胞死亡过程,见于胚胎发育、组织分化、免疫调节等诸多生理过程和恶性肿瘤、自身免疫疾病等多种病理情况.早期研究细胞凋亡几乎都是体外检测法,如电子显微镜形态学观察,DNA凝胶电泳,ELISA测定核小体,流式细胞仪定量分析法,DNA原位切口末端标记(TUNEL)法等[1].
作者 王荣福
出处 《中华核医学杂志》 CAS CSCD 北大核心 2006年第3期135-136,共2页 Chinese Journal of Nuclear Medicine
  • 相关文献

参考文献15

  • 1Saikumar P,Dong Z,Mikhailov V,et al.Apoptosis:definition,mechanisms,and relevance to disease.Am J Med,1999,107:489-506.
  • 2Collingridge DR,Glaser M,Osman S,et al.In vitro selectivity,in vivo biodistribution and tumor uptake of Annexin V radiolabelled with a positron emitting radioisotope.Br J Cancer,2003,89:1327-1333.
  • 3Boersma HH,Kietselaer BLJH,Stolk LML,et al.Past,present,and future of Annexin A5:from protein discovery to clinical applications.J Nucl Med,2005,46:2035-2050.
  • 4Leppo J.Imaging cell injury and death.Curr Cardiol Rep,2003,5:40-44.
  • 5Kietselaer BLJH,Reutelingsperger CPM,Heidendal GAK,et al.Non invasive detection of plaque instability with use of radiolabeled Annexin A5 in patients with carotid artery atherosclerosis.N Eng J Med,2004,350:1472-1473.
  • 6Aroeuil HD,Rhine W,de Crespigny A,et al.99Tcm-Annexin V imaging of neonatal hypoxic brain injury.Stroke,2000,31:2692-2698.
  • 7Gylys KH,Fein JA,Wiley DJ,et al.Rapid Annexin V labeling in synaptosomes.Neurochem Int,2004,44:125-131.
  • 8Narula J,Strauss HW.Implications of phosphatidylserine(PS) reversal in acute ischemic syndromes.J Nucl Med,2003,44:397-399.
  • 9Bai JH,Wang P,Chapman ER.C2A activates a cryptic Ca2+ -triggered membrane penetration activity within the C2B domain of synaptotagmin I.Proc Natl Acad Sci USA,2002,99:1665-1670.
  • 10Zhao M,Beauregard DA,Loizou L,et al.Non invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent.Nature Med,2001,7:1241-1244.

二级参考文献47

共引文献27

同被引文献84

引证文献5

二级引证文献50

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部