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纳米粒作为脑靶向给药系统的研究进展 被引量：5

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摘要 血脑屏障(BBB)使得大部分药物不能进入脑内。纳米粒给药系统能够透过血脑屏障,提高脑内药物浓度,是实现脑靶向给药的良好载体。本文综述了国内外关于纳米粒脑靶向给药的最新研究进展,讨论了纳米粒制备和性质评价的方法、纳米粒透过血脑屏障的机制以及纳米粒透过BBB的体外模型和体内外评价方法,并结合当前研究存在的问题进行了展望。
作者 王永 陆兵 朱厚础
机构地区 中国人民解放军军事医学科学院生物工程研究所
出处 《解放军药学学报》 CAS 2006年第3期202-205,共4页 Pharmaceutical Journal of Chinese People's Liberation Army
基金 北京市自然科学基金 No.7042053
关键词 纳米粒 血脑屏障 脑靶向
分类号 R944 [医药卫生—药剂学]
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参考文献28

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二级参考文献52

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共引文献45

同被引文献69

引证文献5

二级引证文献15

解放军药学学报
2006年 第3期

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