安定持续静滴控制中重度新生儿缺氧缺血性脑病惊厥的观察

Clinical Observation of Continuous Intravenous Drip of Valium to Control Convulsion in Neonates with Moderate or Severe Hypoxic Ischemic Encephalopathy

目的观察持续静滴安定控制中重度新生儿缺氧缺血脑病(HIE)惊厥的疗效。方法选择中重度HIE出现频繁惊厥或惊厥持续状态患儿33例,其中治疗组18例给予安定持续静滴治疗,对照组15例间断给予镇静剂。比较惊厥控制时间。结果治疗组惊厥控制时间(30.39±10.68)min较对照组(60.87±9.49)min明显为短(t=8.65,P<0.01)。在0.05mg/(kg·min)剂量范围内未出现呼吸抑制等明显副作用。结论安定持续静滴控制中重度HIE惊厥发作临床效果良好、安全。

Objective To observe the curative effect of continuous intravenous drip of valium to control convulsion in neonates with moderate or severe hypoxic ischemic encephalopathy （ HIE）. Methods Thirty three cases of moderate or severe HIE with frequent or sustaining convulsion were divided into treatment group （ n = 18, continuous intravenous drip of valium） and control group （n = 15, intem^ittent treatment with sedative）, The controlling time for convulsion was compared between the two groups. Results The controlling time was （30.39 ± 10.68） minutes in the treatment group and （60.87 ± 9.49） minutes in the control group, there was significant difference between the two groups （P 〈 0,01）. There was not obvious side effect like respiratory inhibition were observed within the dose of 0.05mg/（ kg, min）. Conclusions The continuous intravenous drip of valium to control convulsion in neonates with moderate or severe HIE is safe and has good clinical effect.