阿托伐他汀对冠心病患者血清细胞因子水平影响的研究

Effect of Atorvastain on Serum Level of Cytokine in Patients with Coronary Artery Disease

目的探讨阿托伐他汀对冠心病患者血清细胞因子水平的影响。方法用酶联免疫吸附法和常规酶法测定45例常规治疗组和45例阿托伐他汀治疗组冠心病患者治疗前后血清可溶性细胞间粘附分子-I(ICAM-I)、肿瘤坏死因子-α(TNF-α)水平以及总胆固醇(TC)水平的变化。结果与常规治疗组相比,阿托伐他汀组患者治疗4、8周后I-CAM-I、TNF-α以及TC水平均明显降低(P均<0.05),并且上述三个因子水平治疗4、8周后均呈逐渐下降趋势。结论阿托伐他汀可以降低冠心病患者血清ICAM-1和TNF-α水平,减轻冠心病的炎症反应,并且这种机制独立于降脂作用以外。

Objective To investigate the effects of atorvastain on serum level of cytokine in the patients with coronary artery.disease. Methods The serum level of intercellular adhesion molecule （ ICAM- 1 ）, tumor necrosis factor （TNF- α） and totalcholesterol （TC） of patients in the control group （n=45, routine treatment） and treatment group （n = 45, atorvastain treat-ment） were measured by enzyme linked immunosorbent assay （ELISA）and routine enzyme method （REM） before and after the management. Results The serum level of ICAM - 1, TNF- α and TC in the treatment group was lower than that in the con-trol group 4 and 8 weeks after administration （ P 〈 0.05）, and decreased significantly （ P 〈 0.05）. Conclusions Atorvastaincan decrease serum level of ICAM- 1, TNF-α and TC, and have beneficial effect on coronary artery disease.