慢性阻塞性肺疾病继发肺部真菌感染危险因素的临床研究

Clinical Study on Secondary Pulmonary Fungus Infection of Patients with Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病(COPD)患者继发肺部真菌感染的危险因素。方法回顾性分析26例继发肺部真菌感染及20例无继发真菌感染的COPD患者的临床资料。结果26例患者中有3例为反复感染、20例为白色念珠菌感染;和对照组比较发现呼吸机使用时间、激素使用剂量及抗生素应用时间和真菌的继发感染呈正相关。结论呼吸机、激素及抗生素应用时间为COPD患者继发真菌感染的危险因素。

Objective To investigate the risky factors of seconday pulmonary fungus infection of patients with Chronic Ob structive Pulmonary Disease. Methods The clinical data of 46 COPD were analyzed, including 26 cases with secondary pulmonary fungus infection. Results 3 cases had secondary pulmonary fungus infection repeatedly. 20 cases were candida albicans infection. Compared with the control group, the period of artificaial ventilation, use of corticosterioids and antibiotics had positive correlation with the secondary infection of pulmonary fungus. Conclusions The use of artificaial ventilation, corficosterioids and antibiotics were the risky factiors of secondary pulmonary fungus infection of patients with COPD.