硫酸镁预防冠状动脉搭桥术后拔管反应的临床应用研究

Effect of Magnesium Sulfate for Postoperative Extubation Response in Patients with Coronary Artery Bypass Graft

目的探讨硫酸镁对预防冠状动脉搭桥术后拔管反应的效果。方法60例非体外循环下冠状动脉搭桥术(OPCAB)患者被随机化分为治疗组和对照组,每组30例,术后当患者符合拔管指征,准备行气管拔管时,治疗组快速静注硫酸镁50mg/kg,对照组静注等量生理盐水。结果治疗组MAP、HR拔管前后均无明显变化(P>0.05);对照组吸痰时、拔管时、拔管后5min和10min的MAP、HR均明显高于入室时水平,和治疗组比较差异具有显著性(P<0.01);对照组有3例发生室性早搏。结论硫酸镁可有效减轻冠状动脉搭桥术后拔管期心血管不良反应,减少心律失常的发生。

Objective To evaluate the effect of magnesium sulfate to prevent postoperative extubation response in patients received coronary artery bypass graft （CABG）. Methods Sixty cases received off-pump coronary artery bypass graft （OPCABG） were divided into 2 groups （n = 30） randomly, the treatment group （2 rain before endotracheal intubation drawing, quickly iv. magnesium sulfate, 50 mg/kg. ） and control group （iv. commensurate normal saline ）. Results The mean artery prrssure （MAP） and heart rate （HR） of the therapy group changed slightly before and after extubation （P 〉0.05）, whereas the value increased obviously in the control group in the operation of extubation （P 〈 0.01 ）. Three cases with the premature contraction was found in the control group. Conclusions Magnesium sulfate can decrease effectively the cardiovascular adverse reaction, especially the arrhythmia, during the extubation in the patients received OPCABG.