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芦荟大黄素对人胃癌细胞株SGC-7901的增殖抑制作用 被引量:5

INHIBITION EFFECT OF ALOEEMODIN ON HUMANGASTRIC CANCER CELL LINE SGC-7901
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摘要 目的:是研究芦荟大黄素对胃癌细胞株SGC-7901的增殖抑制作用。方法:空白对照组加培养基、阴性对照组加2‰DMSO、阳性对照组加5-氟尿嘧啶、芦荟大黄素组(终浓度分别为25μg/mL、50μg/mL、100μg/mL);孵育12、24、48h;采用MTT法观察增殖抑制作用。结果:芦荟大黄素在25μg/mL^100μg/mL浓度范围内作用12h,对人胃癌细胞株SGC-7901的增殖没有明显的抑制作用,作用24h和48h时能起到显著的抑制作用(P<0.05)。结论:芦荟大黄素能明显抑制人胃癌细胞株SGC-7901的增殖。 Objective:To explore the inhibitory effects of aloeemodin on human gastric cancer cell line SGC - 7901. Methods: The experiment was derided into control, DMSO, 5 - FU and aloeemodin ( 25 μg/mL,50 μg/mL, 100μg/mL) groups, incubating time was respectively 12,24,48h. MTT assay was used to analyze the proliferation. Results:aloeemodin (25-100μg/mL)clearly inhibited the multiplication of Human SGC -7901 cells within 24 and 48 hours ( P 〈0.05 ), but had no inhibitory effect within 12 hours. Conclusion: Aloeemodin has significant inhibitory effect on gastric cancer cell SGC -7901.
出处 《牡丹江医学院学报》 2006年第4期8-11,共4页 Journal of Mudanjiang Medical University
基金 黑龙江省自然基金资助课题(NO.TD2005-01)
关键词 芦荟大黄素 胃癌 MTT Aloeemodin Gastric Cancer MTT
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