摘要
目的:研究干扰素-γ诱导因子白细胞介素-18(IL-18)血清浓度与冠心病临床不稳定情况,即急性冠状动脉综合征(ACS)之间的关系。方法:采用酶联免疫吸附法(ELISA)检测68例冠心病患者和31例正常健康者血清IL-18、IL-10的水平,并比较上述指标水平与急性冠状动脉综合征之间的关系。结果:血清IL-18水平在急性心肌梗死(AM I)组和不稳定性心绞痛(UAP)组显著高于稳定性心绞痛(SAP)组和对照组,在AM I组和UAP组患者之间血清IL-18水平无显著性差异,血清IL-10水平在AM I组和UAP组则明显低于SAP组和对照组;SAP组血清IL-10水平也低于对照组。结论:急性冠状动脉综合征患者血清IL-18水平明显升高且与抗炎因子IL-10呈负相关关系;IL-18可能是促进斑块不稳定而发生溃疡、破裂、急性血栓形成从而导致急性冠状动脉综合征的重要因素。
Objective ：To investigate the relationship between serum density of interleukin- 18（ IL- 18） induced by interferon -γ（ IFN -γand clinical unstability of Coronary Heart Disease （CHD） or called Acute Coronary Syndrome （ACS）. Methods：To examine the serum density of IL - 18 and IL - 10 of 68 cases CHD patients and 31 cases health people using enzyme linked immunosorbent assay（ELISA）, and to compare the relation between their serum density and ACS. Results ：The serum density of IL- 18 in Acute Myocardial Infarction （AMI） group and Unstability Angina Pectoris（UAP） group were obviously higher than serum density in Stability Angina Pectoris（SAP） group and control group. There was not difference in serum density of IL - 18 between AMI group and UAP group. Serum density of IL -10 in SAP group was lower than control group. Concluslon：The serum density of IL -18 in ACS patients is obviously higher than health people and shows negative correlation with anti - inflammatory factor IL - 10. IL - 18 maybe an important reason to promote instability of coronary plaque and ulceration, rapture, acute thrombosis, then to result in ACS.
出处
《牡丹江医学院学报》
2006年第4期12-16,共5页
Journal of Mudanjiang Medical University
