摘要
Objectives: To determine if tracheal lavage concentrations of the transcriptio n factor NF-κB, which is activated by risk factors associated with bronchopulm onary dysplasia (BPD) and induces expression of cytokines associated with BPD, i s related to BPD in premature infants. Design: Serial tracheal lavage samples fr om intubated premature infants were analysed for cell count and concentrations o f interleukin (IL)8 and NF-κB, corrected for dilution by secretory component concentrations. Setting: Level III university hospital neonatal intensive care un it. Patients: Thirty three intubated infants (mean (SD) birth weight 903 (258) g, median gestation 27 weeks (range 24-31)-) in the first 14 days of life. Main outcome measures: Tracheal effluent NF-κB, IL-8, and cell counts, corrected for dilution by secretory component measurement. Results: Square root transforme d NF-κB concentrations were significantly related to signs of inflammation (ce ll count, P = 0.002; IL-8, P = 0.019) and to simultaneous fraction of inspired oxygen in samples from the first 3 days of life (P = 0.512, P < 0.003). Of the 3 2 subjects with samples in the first 3 days of life, the half who either died or had BPD had higher NF-κB concentrations than those without BPD (square root c oncentration 0.097 (0.043) vs 0.062 (0.036) μg/μg protein/μg secretory compon ent, P = 0.018). Conclusions: Tracheobronchial lavage NF-κB concentrations are related to lung inflammation, oxygen exposure, and pulmonary outcome in intubat ed preterm infants. NF-κB activation may be an early critical step leading to BPD.
Objectives： To determine if tracheal lavage concentrations of the transcription factor NF - κB, which is activated by risk factors associated with bronchopulmonary dysplasia （BPD） and induces expression of cytokines associated with BPD, is related to BPD in premature infants. Design： Serial tracheal lavage samples from intubated premature infants were analysed for cell count and concentrations of interleukin （IL） 8 and NF -κB,
