摘要
过氧化物增殖体活化受体（PPAR）是治疗2型糖尿病等人类代谢疾病的新靶点。与单一的PPARγ激动剂相比，PPARα／γ双重激动剂可以产生协同作用，更具有开发潜力，是更好的2型糖尿病药物。现综述α-烷氧基苯基丙酸类、苯氧异丁酸类、苄基丙二酸衍生物类及其它类型的PPARα／γ双重激动剂的研究进展。并提出一些研究思路。
Peroxisome proliferator - activated receptors （ PPAR ） is a new target for the treatment of metabolic diseases including type 2 diabetes. Compared with single PPART agonists, PPAR α/γ dualagonists cooperate each other, and are more potential. Advances in study of α - alkyloxy phenylpropionic acids, phenoxyisobutyric acids, benzyl malonic esters and some other types of PPARα/γ dual agonists are reviewed to Classify in this paper, and some proposals on their researches are given.
基金
湖南省教育厅自然科学基金资助项目（06C053）
