大黄素对鹌鹑脂肪肝疗效的比较研究

Comparison of Curative Effects of Emodin on Fatty Eivers of Quails

目的 观察大黄素对鹌鹑实验性脂肪肝的影响。方法 将鹅鹑随机分为7组，喂以不同饲料，用高脂饲料复制鹌鹑脂肪肝的模型。8用后对肝脏进行肉眼和病理组织学检查，并测定血清中TC、TG和HDL-C／TC比值。结暴 喂高脂饲料的第2组肝脏出现明显的脂肪变性，肝系数增大，血清、TC、TG增高，HDL-C／TC比值降，与第1组（普饲对照组）相比有显著性差异（P〈0．05）。培高脂饲料加大黄素的3-5组、加降脂药的6组、加维生素的7组与第1组比较各项指标无显著性差异；与第2组比较，肝脂肪变性各项指标明显减轻，有统计学意义（P〈0.05）。结论 大黄素具有抑制肝脂肪病变的作用。

Objective To observe the effects of emodin on experimental fatty livers of quails.Methods The quails were divided into 7 groups, fed with different forages. The model fatty livers of quails were reproduced with synthetic method. Eight weeks later, the livers were examined in histopathology as well as with the naked eyes. The ratios of TC, TG and HDL-C/TC in serum were measured.Results There appeared obvious fatty change in the livers in group two fed with high fat forage, and the liver coefficient increased, serum TC raised and the ratios of HDL-C/TC decreased, the difference being remarkable compared with group one （P 〈 0. 05 ） . Compared with group 1, all the indexes in groups 3 - 5 of hyperlipemia plus different dosages of Emodin and groups 6 - 7 of lipid-reducing drugs and vitE had no remarkable diffeenee. But compared to group 2, all the indexes decreased with statistical significance （ P 〈 0.05 ） . Conclusion Emodin can cause the inhibition of fatty change in liver.