前列腺增生症雄激素受体含量研究

Study of Androgen Receptor Content in Human BPH

检测16例良性前列腺增生症手术标本分出外周区和移行区,对每区组织的胞核和胞浆中雄激素受体(AR)含量进行测定,采用葡聚糖活性炭吸附饱和分析法。对照组8例正常前列腺标本亦测定胞核和胞浆中AR含量,结果BPH胞浆中的AR明显高于正常前列腺组织含量。分析了AR在人类BPH的发生和维持中的作用。

Both periheral and transitional zones of benign prosfatic hypertrophy (BPH)specimens were distinguished by McNeal's method. AR contents of cytosol and nuclei of each zone were measured in 16 specimens of human BPH by DCC method. Cytosolic and nuclear AR contents in 8 specimens of normal prostate were measured for control. The results revealed that the cytosolic AR content in BPH was much higher than that in normal prostate. The role of AR was discussed in the pathogenesis and development of human BPH.