梗阻性黄疸血流动力学变化及转归研究

Hemodynamic Changes and Their Outcome in Obstructive Jaundice

报道73例梗阻性黄疸和39例单纯胆囊结石(G组)血流动力学变化及转归.根据研究目的将梗阻性黄疸分为<60岁非吲哚美辛组(A组),吲哚美辛术前组(B组),吲哚美辛术后组(C组),胆道恶性梗阻(D组),胆道良性梗阻(E组)和老年胆道梗阻(F组)。结果表明梗阻性黄疸各组SV、CO和CI显著高于G组(均P<0.01),MAP、SVR和PVBF显著低于G组(均P<0.01)。B组和C组MAP、SVR和PVBF显著高于A、D,E和F组(均P<0.01),与G组比较也有极显著性差异(P<0.01)。因此认为吲哚美辛有改善循环功能、PVBF和肝功能作用,解除胆道梗阻后上述指标进一步改善。

Hemodynamic changes and their outcome were studied in 73 patients with obstructive jaundice and 39 cases with simple gallbladder stones (group G). Obstructive jaundice patients were subgrouped into non-in-domethacin group (group A), pre-operative indomethacin group (group B), post-operative indomethacin group (group C). Group A was further subgrouped into malignant obstruction (group D),benign obstruction (group E),and elderly patients with obstructive jaundice (group F). The results showed that stroke volume (SV), cardiac output (CO) and cardiac index (CD were higher in every group of obstructive jaundice than those in group G (P<0. 01),and mean artery pressure (MAP),stroke vessel resistance (SVR) and portal vein blood flow (PVBF) in ervery group of obstructive jaundice were lower than those in group G. MAP, SVR and PVBF in group B and group C were obviously higher than those in group A,group D,group E and group F (P<0.01) .but comparing MAP,SVR and PVBF in gr.oup C with those in group G there were marked differences (P<0. 01). Therefore,it was suggested that indomethacin may improve circulation function,.PVBF and liver function in obstructive jaundice,the functional indexes were improved following the decompression of bile duct.