饮食及针刺因素对单纯性肥胖大鼠外周血中Leptin的影响

Affection of Serological Leptin by Crash Diet and Acupuncture Treatment on Experimental Simple Obesity Rats

【目的】通过对肥胖大鼠进行饮食控制、针刺治疗,观察外周血Leptin的改变,进一步探讨减肥的有关机制。【方法】建立单纯性肥胖大鼠模型,控制饮食及针刺治疗,观察大鼠体重、脂肪量、Lee's指数,各部位的脂肪量以及血脂和Leptin的变化。【结果】针刺后肥胖大鼠的体重、Lee's指数、心包等各部位脂肪量均低于治疗前(P<0.05),同时血清胆固醇和甘油三酯、低密度脂蛋白含量降低(P<0.05),高密度脂蛋白含量升高(P<0.05),血清Leptin水平明显降低(P<0.01),控制饮食也有一定的效果。【结论】针刺对单纯性肥胖大鼠有减肥作用,可能与降低血清中Leptin浓度,改善血脂水平有关。

[Objective]To study the changes of leptin on obesity rats treated By diet control and acupuncture. [Methods]The body weight, TC, TG , Leptin and correlated norm were observed on fat rats treated by crash diet and acupuncture. [Results]The results showed that acupuncture had effect on the body weight, Lee＇s index, fatty amount of body, contents of TG, TC, LDL-C and Leptin, which were all decreased obviously（ P 〈 0.05）, and HDL increased（ P 〈0.05）. [Conclusion]The regulation of acupuncture on leptin may be related to the antiobesity effect for simple obesity.