晚期卵巢上皮性癌的治疗及预后分析

Treatment and Prognostic Factors of Advanced Epithelial Ovarian Cancer

【目的】探讨晚期卵巢上皮性癌的治疗及预后影响因素。【方法】回顾性分析87例晚期卵巢上皮性癌的临床病理资料,应用COX风险比例模型判断影响预后的因素。【结果】多因素分析显示,临床分期、残余灶大小及术后化疗的疗程数是影响预后的重要因素。【结论】满意的肿瘤细胞减灭术及术后规则化疗可以改善晚期卵巢上皮性癌的预后。

[Objective]To study the treatment results and prognostic factors of advanced epithelial ovarian cancer. [Methods]The data of 87 patients presenting between Jan. 1993 and Dec. 1998 were analyzed retrospectively. Survival was calculated by Kaplan-Meier method and comparison was performed using Log-Rank test. Independent prognostic factors were identified by the COX proportional hazards regression model. [Results]Multivariate analysis showed that clinic stage, residual tumor and the number of course of chemotherapy were the most important prognostic factors. [Conclusion]Optimal surgical debulking and postoperative standard chemotherapy can improve survival of advanced cancer patients.