川崎病患儿血清内皮素-1的变化与冠状动脉病变的关系

Relation of Plasma Endothelin 1 and Coronary Arterial Lesions in Children with Kawasaki Disease

【目的】观察川崎病(KD)患儿血清内皮素-1(ET-1)的变化及其与冠状动脉病变之间的关系。【方法】42例KD患儿根据病期分为急性期和恢复期;依据心脏超声检查分为冠脉病变组和非冠脉病变组。采用放免法测定ET-1水平并进行各期组间的比较。【结果】KD急性期患儿ET-1为(87.46±16.79)ng/L明显高于恢复期组(52.53±19.26)ng/L和健康对照组(43.31±18.35)ng/L(P<0.01)。冠脉病变组急性期水平(96.82±18.34)ng/L高于非冠脉病变组(75.21±14.50)ng/L(P<0.01)。【结论】内皮素可能参与了KD的发病机制,ET-1水平可反映KD冠脉血管受累的严重程度。

[Objective]To investigate the ralation of plasma endothelin 1 （ET-1） and coronary lesions in children with Kawasaki disease （KD）. [Methods]Forty two KD patients were divided into acute and convalescent stages with or without coronary arterial lesions. The concentration of plasma ET-1 was determined with radioimmunoassay in children with Kawasaki disease and healthy children as controls . [Results]The plasma ET-1 in KD during acute phase was significantly higher than that during convalescent phase and healthy controls （ P〈0. 01） , the plasma ET-1 level in patients with coronary arterial lesions was significantly higher than that without coronary arterial lesions （ P〈0.01 ）. [Conclusion]The endothelin may play an important role in the pathogenesis of KD, and the high plasma ET-1 level may relate with severity of coronary artery lesion.