小儿原发性肾病综合征频繁复发的危险因素

Risk Factors for Frequent Relapse in Children with Idiopathic Nephrotic Syndrome

【目的】探讨小儿原发性肾病综合征频繁复发的危险因素,以便尽早判断激素依耐调整治疗方案。【方法】对108例原发性肾病综合征患儿随访至少1年以上进行以医院为基础的回顾性研究,所获数据采用非条件Logistic回归分析。【结果】108例患者中有53.7%复发,单因素、多因素分析结果均显示治疗疗程选择,反复使用白蛋白,初次激素治疗达缓解所需天数,反复感染,为其主要相关危险因素。【结论】发现有危险因素的患者,选择适当的治疗方案、足够长的疗程、防治感染、避免劳累、加强管理、规范治疗是减少复发的重要环节。

[Objective]To determine the predictive risk factors for the development of frequent relapse in children with idiopathic nephrotic syndrome（INS）. [Methods]A retrospective study of 108 children with INS, followed for at least 12 months , was conducted. Related following parameters were studied as predictors of frequent relapse. [Results]Of the 108 children fulfilled the inclusion criteria,53.7 % frequently relapsed. Both univariate and logistic regression analyses revealed that initial remission time ,concomitant infections during relapses, repeated intravenous albumin infusion , time of therapy were significant predictors of frequent relapse. [Conclusion]In order to diminish relapse rate the clinician should identify those children with predictive factors of frequent relapse,select proper therapeutic regimen for them ,and ask them to avoid exertion, prevent and cure their infection.